A spindle cell tumors like fibrosarcoma and provisional diagnosis of pyogenic granuloma malignant peripheral nerve sheath tumor. Basal cell carcinoma bcc, the most common skin cancer and the most common of all. Spindle cell hemangioma is an uncommon benign vascular tumor of the oral cavity. Spindle cell lesions of the breast represent an interesting diagnostic problem, as the differential diagnoses are wide. The spindle cells were arranged in storiform and haphazard pattern. Scc occurs in the oral cavity, larynx, breast, kidney, uterus, conjunctiva, prostate, other organs, and occasionally in the lungs. Pdf the spindle cell neoplasms of the oral cavity researchgate. Spindle cell carcinoma is a relatively rare tumor occurring often in the oral cavity, upper respiratory tract, and less frequently in the esophagus and skin.
The term inflammatory myofibroblastic tumor imt has been used to describe a wide and heterogeneous group of spindle cell proliferations, ranging from reactive lesions to benign neoplasms and lesions that behave more aggressively or even in a malignant way. With the exception of ks, there was a general paucity of malignant soft tissue tumors. We present a case of sch in the upper lip of a 41yearold woman. Pdf spindle cell variant squamous cell carcinoma of the. Spindle cell lesions affecting oral mucosa are quite diverse in nature and their diagnosis is always a challenge. Sarcomatoid carcinoma sc is a rare variant of squamous cell carcinoma which is characterized by a dysplastic epithelial component and a stromal element with invasive fusiform or spindle shaped cells. Spindle cell carcinoma of the tongue combined with double primary. Spindle cell tumors are rare in the maxillofacial region and usually harbor a wide range differential diagnosis including lesions which are both benign and malignant in nature. The patients were 23 men and 12 women, with a mean age of 55. Benign and malignant proliferative fibroosseous and. Inflammatory myofibroblastic tumour of paranasal sinuses with. After 14 months the patient is free of disease with easily intelligible speech and normal swallowing. Pdf spindle cell carcinoma of the oral cavity researchgate.
Spcc occurs commonly in 67th decades of life and represents a male predominance. Granular cell lesions of the oral mucosa, jaws, and salivary glands constitute a heterogeneous group of lesions which may be either odontogenic, salivary gland, or metastatic in origin. Seminar on spindle cell tumors of the oral cavity part iii by. Spindle cell carcinoma, is an unusual and highly malignant variant of squamous cell carcinoma comprising upto 3% of squamous cell carcinomas in the head and neck region with propensity for occurrence in the larynx followed by the oral cavity and the nasal cavity. We report an extremely rare case of spindle cell carcinoma of the sinonasal cavity. These neoplasms occurred most frequently on the lower lip, tongue, and alveolar ridge in either polypoid, exophytic, or endophytic configurations.
Pulmonary spindle cell carcinoma with unusual morphology. Spindle cell neoplasms are defined as neoplasms that consist of spindleshaped cells in the histopathology. Pulmonary spindle cell carcinoma pscc, also known as sarcomatoid carcinoma sc or pseudosarcoma, is a high malignant variant of carcinoma, which is derived from epithelium, but exhibits characteristics of mesenchymal differentiation. In total, benign neural tumors accounted for 21% of all cases seen. Spindle cell carcinoma spcc an aggressive squamous cell carcinoma, variant, frequently. Case report spindle cell squamous carcinoma of the tongue in a child. Pdf classification of giant cell lesions of the oral. Spindle cell hemangioma in the mucosa of the upper lip. Spindle cell carcinoma of the mandibular gingiva a case report. Spindle cell carcinoma of the nasal cavity sachin gupta. Granular cell tumor clinical features fm, 4th to 6th decade solitary lesion, primarily involving the. Department of oral and maxillofacial surgery, kobe university graduate school of medicine. Spindle cell carcinoma of the oral cavity oral surgery, oral.
Inflammatory myofibroblastic tumour of paranasal sinuses. Imt usually follows a benign clinical course after radical excision, but invasive, locally recurrent, and metastatic forms of abdominal and. A look at the biology of spindle cell squamous carcinoma of the oral cavity. Since the lesions were multiple, the patient healed uneventfully with no small and appeared to be benign, the 2012 international journal of oral and maxillofacial pathology. Palatal solitary neurofibroma simulates a salivary gland. Expression of melanocytic differentiation markers in malignant melanomas of the oral and sinonasal mucosa. May 19, 2017 spindle cell neoplasms are defined as neoplasms that consist of spindle shaped cells in the histopathology. Download fulltext pdf download fulltext pdf read fulltext. As the list of ulcerative lesions in the oral cavity is quite extensive, the focus here will be. Nina zidar, nina gale, in encyclopedia of cancer third edition, 2019. Spindle cell carcinoma spcc, also referred to as sarcomatoid carcinoma, is a biphasic tumor composed of conventional scc and malignant spindle cells.
In the oral cavity, the origin of the spindle cell neoplasms may be traced to epithelial, mesenchymal and odontogenic components. Spindle cell carcinoma of the mandibular gingiva a case. The clinical and pathologic features of eight cases of spindle cell lipoma affecting the tongue were analyzed. The study group included five men and three women ranging in age from 35 to 80 years mean 57. Spindle cell neoplasms can affect the oral cavity and it is often very difficult for the oral pathologists to differentiate it from other similar microscopic simulates. Inflammatory myofibroblastic tumours imts are clinicopathologically distinctive but biologically controversial entities, which have been described in the lungs, abdomen, retroperitoneum, and extremities, but rarely affect the head and neck region. It includes neural, myofibroblastic, muscle, fibroblastic, vascular, epithelial, odontogenic and miscellaneous tumors. Pdf the immunohistochemical profile of oral inflammatory. Spindle cell lipoma of the oral cavity sciencedirect.
The margins of resections are free of tumour and the neck dissection specimens were negative of cancer figure 2. However, it is now recognized that this lesion can also occur in other locations, including the oral cavity. In the oral cavity, myofibroma occurs within the submucosal or intramuscular tissue and has a predilection by the tongue, buccal mucosa and lips. Our patient was free of lymph node metastasis but mandibular bone was invaded. Benign and malignant proliferative fibroosseous and osseous. Spindle cell lipoma scl is a variant of lipoma, usually presenting in the neck or trunk. Granules in granular cell lesions of the head and neck. Pdf classification of giant cell lesions of the oral cavity. Pdf mucoepidermoid carcinoma with spindle cell change. The spindle cell neoplasms of the oral cavity ncbi nih. Who classification benign odontogenic epithelium without odontogenic ectomesenchyme ameloblastoma squamous odontogenic tumor pindborgs tumor clear cell odontogenic tumor odontogenic epithelium with odontogenic ectomesenchyme with or without dental hard tissue formation.
Spindle cell soft tissue neoplasms are rarely reported in the oral cavity and account for. In salivary gland tumors, neoplastic myoepithelium is 2005. Jun 01, 2003 in total, benign neural tumors accounted for 21% of all cases seen. Presence of this tumor type in the tongue has rarely been reported.
A 75yearold man was admitted to our hospital because of right nasal obstruction. Oral ulcers are diagnosed based on the patients history,clinical appearance, site, duration and frequency and the underlying systemic condition furthermore, histopathology also aids in a definitive diagnosis for the majority of ulcerative lesions. Leiomyosarcoma of palate is a rare malignant spindle cell tumour in oral cavity. Clinicopathological and immunohistochemical analysis of. Granular cells in these proliferations most commonly are the result of lysosomal accumulation, aging, degenerative, metabolic alteration, increased apoptosis, cytoplasmic autophagocytosis, and many more. Seminar on spindle cell tumors of the oral cavity part i by. This may reflect either the true rarity of these tumors in the oral cavity or the practice patterns whereby many malignant spindle cell tumors are seen in more specialized pathology services. Spindle cell carcinoma spcc is a relatively rare malignancy affecting the upper aerodigestive tract.
Pdf on jan 1, 2017, pournima godge and others published spindle cell carcinoma of the oral cavity. Pdf spindle cell lesions of the breast the pathologic. The most common site of origin in head and neck region is larynx particularly vocal cords and hypopharynx. The result of intraoperative frozen section showed a diffuse distribution of a short spindle cell tumor without obvious atypism, which was accompanied by inflammatory cell infiltration. In the strict sense,the word does not imply atissue. Spindle cell carcinoma is a rare biphasic tumor consisting of epithelial and mesenchymal components. Specimen margins were free of tumors in 11 patients. In the strict sense,the word does not imply a neoplastic process. Head and neck spindle cell carcinoma cleveland clinic journal of.
Spindle cell carcinoma spcc is referred to as a variant of oral squamous cell. Nov 30, 2017 spindle cell hemangioma sch is a unique benign vascular lesion. For biopsies from the head and neck assessment is further complicated by the range of tissues present at this site, and the limited amount of. Spindle cell carcinoma is an unusual variant of squamous cell carcinoma. Myofibroma is an uncommon spindle cell neoplasm rarely found in oral cavity. A, the tumors were composed of a combination of mature adipocytes and bland spindled cells. A tumor, by definition, is simply a swelling of thea tumor, by definition, is simply a swelling of the tissue.
Mark anderson dds, ms university of tennessee college of dentistry. Cited from american joint committee on cancer ajcc cancer staging man. According to previous studies, spindle cell carcinoma spcc is an unusual form of divergent differentiated squamous cell carcinoma scc, which consists of elongated spindle epithelial cells and resembles a sarcoma. Spindle cell carcinoma spcc is a unique and challenging variant of squamous cell carcinoma scc. The histological diagnosis of spindle cell lesions can be challenging in any. Oct 01, 1995 five cases of spindle cell lipoma have been reported in the oral cavity, two af fecting the anterior floor of the mouth, two the tongue, and one the hard pal ate4,81 a case reported to occur in the cheek2 is not included, as it was not specifically stated that the tumor oc curred in the mouth. Jan 01, 2020 various spindle cell neoplasms of oral cavity include neural, myofibroblastic, muscle, fibroblastic, vascular, epithelial, odontogenic and other miscellaneous tumors. Lipoma uncommon neoplasms that may occur in any region of the oral cavity buccal mucosa, tongue, and floor of the mouth asymptomatic, yellowish submucosal masses granular cell tumors, neurofibromas, traumatic fibromas, and salivary gland lesions mucocele and mixed tumor adipocytes consists of a wellcircumscribed. In the oral cavity, the origin of the spindle cell neoplasms may be. Introduction spindle cell lesions affecting oral mucosa are quite diverse in nature and their diagnosis is always a challenge. Spindle cell lipoma is typically seen in the necktrunk region of middleaged and older men. An entity described as myxoid lipoma of the oral cavity has rarely been reported but appears to be more properly classified as spindle cell lipoma. Spindle cell carcinoma an overview sciencedirect topics.
Granular cell tumor clinical features fm, 4th to 6th decade solitary lesion, primarily involving the dorsal tongue asymptomatic sessile. The incidence rate of spindle cell carcinoma is about 0. Pdf spindle cell neoplasms are defined as neoplasms that consist of spindleshaped cells in the histopathology. Spindle cell tumor in oral cavity international journal of. Here, we report the clinicopathological features of two oral scls low. Spindle cell lipoma should be considered in the differential diagnosis of oral cavity mesenchymal tumors. Typically, this lesion is seen in neonates and infants with few cases reported in adults patients. Lip and oral cavity 10320 naaccr 202014 webinar series 2 lip and oral cavity overview 4 20 estimated new cases and deaths new cases.
It is often misdiagnosed with other benign lesions like nodular fasciitis, clinical. Pulmonary spindle cell carcinoma pscc is a highly malignant carcinoma. Aug 09, 2017 spindle cell lesions of oral cavity part i 1. Spindle cell squamous carcinoma verrucous carcinoma mucosal melanoma. We present a case of a 51yearold man with a soft tissue mass in the. Diagnosis and treatment of this rare tumour in this. Spindle cell carcinoma, also termed carcinosarcoma, pseudosarcoma, polypoid carcinoma, sarcomatoid carcinoma, and spindle cell variant of squamous cell carcinoma, is a rare type of malignant tumor that often grows as an exophytic polypoid lesion see also chapter 20. The clinical and histopathologic characteristics make it very difficult to distinguish sc from epithelioid sarcoma es. International journal of contemporary medicine surgery and radiology.
The mass developed 5 years earlier and enlarged after repeated ethanol injections. Spcc confined solely to the nasal cavity is extremely rare, with only one case having been. Sep 01, 2020 a look at the biology of spindle cell squamous carcinoma of the oral cavity. Tumors have also been reported in the extremities, oral cavity, larynx, bronchus, orbit, scalp, breast, and perianal region 47. Scc occurs in the oral cavity, larynx, breast, kidney, uterus, conjunctiva.
Diagnosis and management of common oral and maxillofacial. The giant cell lesions of oral cavity have been classified on the. Common lesions and conditions of the oral cavity k. Diagnosing this is particularly problematic but important when encountered. The spindle cell neoplasms of the oral cavity europe pmc. Spindle cell soft tissue neoplasms are rarely reported in the oral cavity and account for less. Spindle cell neoplasms comprise a diverse collection of benign and malignant tumors. The head and neck is an embryologically and anatomically complex area, with a number of important structures and organs lying in close proximity to one another. Nasal endoscopy showed a polypoid tumor measuring 3. This classification was based on the predominance of spindle cells in the histopathology of the lesions of the oral cavity.
Gca is a benign, mesenchymal lesion showing histological features intermediate between, but distinct from, solitary fibrous tumor sft and giant cell fibroblastoma gcf of soft tissue. The characteristic spindle cell phenotype of the neoplastic cells in spcc is the result of epithelialmesenchymal transition. Unusual recurrent tongue spindle cell carcinoma with marked. Scc, with the spindle cell component, is an uncommon phenomenon and a rare type of malignant tumor.
May 08, 2015 ossifying fibroma is a rare benign neoplasm in the oral cavity of dogs, 4,10,35,45 while fd is classified as a dysplastic rather than neoplastic process as these lesions tend to be selflimiting. In the upper aerodigestive tract, similar to conventional scc, spcc occurs most commonly in the larynx. Rare cases of oral spindle cell lipoma have been reported. While some are malignant, others are benign or simply reactive in. Only the cells lining the vascular spaces and the epithelioid. Spindle cell variant squamous cell carcinoma of the oral. Spindle cell lipomas infrequently occur within the oral cavity and, in particular, rarely involve the tongue. The mass was elastic firm, mobile, bluish in color, and well demarcated in. Biphasic squamous cell carcinoma and malignant spindle cell stroma larger tumor cells may have hyaline globules.
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